Aimee S. PAYNE,Christoph T. ELLEBRECHT,Vijay BHOJ,Michael C. MILONE
申请号：
US16390763
公开号：
US20190315831A1
申请日:
2019.04.22
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention includes compositions comprising at least one chimeric autoantibody receptor (CAAR) specific for an autoantibody, vectors comprising the same, compositions comprising CAAR vectors packaged in viral particles, and recombinant T cells comprising the CAAR. The invention also includes methods of making a genetically modified T cell expressing a CAAR (CAART) wherein the expressed CAAR comprises a desmoglein extracellular domain.
