THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;NOVARTIS AG
发明人:
BEATTY, GREGORY,ENGELS, BORIS,IDAMAKANTI, NEERAJA,JUNE, CARL H.,LOEW, ANDREAS,SONG, HUIJUAN,WU, QILONG
申请号：
CA2931684
公开号：
CA2931684A1
申请日:
2014.12.19
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Provided are compositions and methods for treating diseases associated with expression of mesothelin. Also provided are a chimeric antigen receptor(CAR) specific to mesothelin, vectors encoding the same, and recombinant T cells comprising the mesothelin CAR. Further provided are methods of administering a genetically modified T cell expressing a CAR that comprises a mesothelin binding domain.
