VAN Bin (US),ВАН Бин (US),ChU Dehniehl (US),ЧУ Дэниэл (US)
申请号：
RU2011108493/04
公开号：
RU0002514937C2
申请日:
2009.07.27
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: claimed invention relates to field of organic chemistry, namely to novel compound of formula (I), where Y and Z, each independently, are selected from group, consisting of: a) phenyl, if necessary substituted with 1 or 2 R6； b) pyridine, imidazole, thiazole, furan, triazole, quinoline or imidazopyridine, if necessary substituted with 1 R6； and c) substituent, independently selected from group, consisting of hydrogen, C1-C6alkyl or pyperidine； R1, R2 and R3, each independently selected from group, consisting of hydrogen and halogen； A and B is each independently selected from hydrogen, OH and C1-C6alkyl； RA and RB are independently selected from group, consisting of hydrogen, C1-C6alkyl and C3-C8cycloalkyl； or RA and RB together with atom, to which they are attached, form 4-6-membered heterocycle, if necessary having additionally one heteroatom or functional heterogrpoup, selected from group, consisting of -O-, -NH, -N(C1-C6-alkyl)- and -NCO(C1-C6-alkyl)-, and 6-membered heterocycle can be additionally substituted with one or two C1-C6-alkyl groups； R4 and R5, each stands for hydrogen； and each R6 is selected from Br, Cl, F, I, C1-C6-alkyl, pyrrolidine, if necessary substituted with one C1-C6-alkyl, C1-C6alkoxy, halogen-C1-C6alkyl, hydroxyl-C1-C6alkylene, -(NRARB)C1-C6alkylene and (NRARB)carbonyl； or to its individual isomer, stereoisomer or enantiomer, or their mixture, if necessary pharmaceutically acceptable salt. Invention also relates to compound of formula (II), particular compounds of formula (I) and (II), pharmaceutical composition and industrial product based on compound of formula (I) and (II), method of treating said pathological conditions, method of obtaining formula (I) compound and to intermediate compound of formula 3.EFFECT: novel compounds, useful as inhibitors of poly(ADP-ribose)polymerase, are obtained.50 cl, 1 tbl, 159 exНастоящее изобретение относится к области органической химии, а именно к новому соединению формул
