3,6-substituted 5-arylamino-1H-pyridine-2-one derivatives and related compounds as poly(ADP-ribose)polymerase (PARP) inhibitors in the treatment of tissue damage or disease caused by necrosis or apoptosis
The invention relates to compounds of formula (I), wherein R1 and R3 independentlyrepresent fluorine, methoxy, -OCF, C-C-alkenylor C-C-Alkyl which is optionally substituted with chlorine,methoxy or one, two or three fluorine atoms； R2 represents hydrogen, fluorine,methoxy, -OCF, C-C-alkenyl or C-C-alkylwhich is optionally substituted with chlorine, methoxy or one, two or three fluorineatoms； X represents O, S, NH or N(C-C-Alkyl)； Ar representsunsubstituted or at least mono-substituted aryl or heteroaryl. Said compoundsare inhibitors of poly(ADP-ribose)polymerase (PARP) and are used in medicamentsfor the treatment of a disease which is selected from the following: tissue damageresulting from cell damage or cell death based on necrosis or apoptosis, neuronallymediated tissue damage or diseases, cerebral ischaemia, head trauma, cerebralapoplexy, reperfusion damage, neurological disorders and neurodegenerativediseases, vascular accidents, cardiovascular disorders, myocardial infarction,myocardial ischaemia, experimental allergic encephalomyelitis (EAE), multiplesklerosis (MS), ischaemia related to heart-surgery, age-related macular degeneration,arthritis, Arterosclerosis, cancer, sceletal- muscle degenerative diseasesresulting in replicative senescence, diabetes and diabetic myocardial diseases.
