MACH, ROBERT H.,REILLY, SEAN,MAKVANDI, MEHRAN,XU, KUIYING,PRYMA, DANIEL A.,GREENBERG, ROGER A.
申请号：
CA3064761
公开号：
CA3064761A1
申请日:
2018.05.24
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present disclosure relates to compounds of Formula I and II, wherein R1-R20 and FL are defined herein. Also provided are methods of targeting alpha-radiation to poly(ADP- ribose)polymerase 1 (PARP-1) enzyme expression, reducing proliferation of cancer cells, reducing proliferation of cancer cells, detecting intact and enzymatically active poly(ADP- ribose)polymerase 1 (PARP-1) enzyme expression, detecting PARP-1 enzyme expression in a subjects tissue sample, monitoring cancer treatment in a subject, or detecting a PARP-1 receptive cancer in a subject.
