KRYSTAL, Mark, R.,WENSEL, David, L.,DAVIS, Jonathan
申请号：
SG11201708441R
公开号：
SG11201708441RA
申请日:
2016.04.14
申请国别(地区):
SG
年份:
2017
代理人:
摘要：
The invention is directed to polypeptides comprising a CD4 binding moiety, a gp41 binding moiety, a HIV fusion peptide inhibitor moiety and combinations thereof. More specifically, the present invention relates to polypeptides comprising a fibronectin-based scaffold domain protein that binds CD4, a fibronectin-based scaffold domain protein that binds the N17 domain of gp41, and a HIV fusion peptide inhibitor or combinations thereof. The invention also relates to the use of the innovative proteins in therapeutic applications to treat HIV.
