KRYSTAL, Mark, R.,WENSEL, David, L,DAVIS, Jonathan
申请号：
PH12017501914
公开号：
PH12017501914A1
申请日:
2017.10.19
申请国别(地区):
PH
年份:
2018
代理人:
摘要：
The invention is directed to polypeptides comprising a CD4 binding moiety, a gp41 binding moiety, a HIV fusion peptide inhibitor moiety and combinations thereof. More specifically, the present invention relates to polypeptides comprising a fibronectin-based scaffold domain protein that binds CD4, a fibronectin-based scaffold domain protein that binds the N17 domain of gp41, and a HIV fusion peptide inhibitor or combinations thereof. The invention also relates to the use of the innovative proteins in therapeutic applications to treat HIV.
