Krystal, Mark R.,,Wensel, David L.,,Davis, Jonathan,
申请号：
AU2019226255
公开号：
AU2019226255A1
申请日:
2019.09.06
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
#$%^&*AU2019226255A120190926.pdf#####ABSTRACT The invention is directed to polypeptides comprising a CD4 binding moiety, a gp41 binding moiety, a HIV fusion peptide inhibitor moiety and combinations thereof. More specifically, the present invention relates to polypeptides comprising a fibronectin-based scaffold domain protein that binds CD4, a fibronectin-based scaffold domain protein that binds the N17 domain of gp4l, and a HIV fusion peptide inhibitor or combinations thereof. The invention also relates to the use of the innovative proteins in therapeutic applications to treat HIV.
