Shenzhen Neptunus Pharmaceutical Research Institute Co.; Ltd.
发明人:
申请号：
EP17860933.5
公开号：
EP3527562A1
申请日:
2017.09.29
申请国别(地区):
EP
年份:
2019
代理人:
摘要：
Provided are a new tubulin inhibitor and applications thereof, said tubulin inhibitor being a series of compounds based on substituted heterocyclic skeletons, targeting the colchicine binding sites of tubulin. The structure is as below: Formula (I), wherein: formula (A), n independently expresses an integer between 0 and 5, the condition being that n≤5, A represents mono- or poly-substituted groups, said groups being selected from the group consisting of H, C1-C20 amide group, C1-C20 acyloxy group, C1-C20 alkanoyl group, C1-C20 alkoxycarbonyl group, C1-C20 alkoxy group, C1-C20 alkylamino group, C1-C20 alkylcarboxyamino group, aroyl group, aralkanoyl group, carboxyl group, cyano group, halogen group, hydroxyl group, nitro group and methylthienyl group.R=
