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新規アミロイド親和性化合物
专利权人:
日本メジフィジックス株式会社
发明人:
谷藤 樹之,中村 大作,高崎 新也,奥村 侑紀
申请号:
JP2009538278
公开号:
JP5313158B2
申请日:
2008.10.24
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
A compound effective as a probe targeting amyloid for image diagnosis and a reagent comprising the compound for detecting amyloid deposited on a biological tissue are provided. Provided are a compound represented by the following formula (1): wherein R 1 , R 2 and R 3 independently represent a group selected from the group consisting of a hydrogen, hydroxyl group, alkyl substituent with 1 to 4 carbon atoms, alkoxy substituent having alkyl chain with 1 to 4 carbon atoms and halogen substituent, excluding the case where two or more of the substituents R 1 , R 2 and R 3 are hydrogen, R 4 is a group selected from the group consisting of a hydrogen, hydroxy group, alkoxy substituent having alkyl chain with 1 to 4 carbon atoms and halogen substituent, and m is an integer of 1 to 4, provided that at least one of R 1 , R 2 , R 3 and R 4 represents a radioactive halogen substituent, and a reagent comprising the same.
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