Peter Birk Rasmussen,Martin Roland Jensen,Klaus Gregorius Nielsen,Peter Koefoed,Florence Dal Degan
申请号：
US12339841
公开号：
US08871212B2
申请日:
2008.12.19
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed are novel methods and compositions for combating diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protein (APP) or beta amyloid (Aβ). Immunization is preferably effected by administration of analogs of autologous APP or Aβ, said analogs being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous Aβ which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Such methods and means include methods for the preparation of analogs and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.
