Zastosowanie immunogenu, poliaminokwas lub koniugat pochodzacy ze zwierzecego APP lub Abeta, immunogenna kompozycja, fragment kwasu nukleinowego i wektor
RASMUSSEN PETER BIRK,PETER BIRK RASMUSSEN,JENSEN MARTIN ROLAND,MARTIN ROLAND JENSEN,NIELSEN KLAUS GREGORIUS,KLAUS GREGORIUS NIELSEN,KOEFOED PETER,PETER KOEFOED,DEGAN FLORENCE DAL,FLORENCE DAL DEGAN
申请号：
PL369099
公开号：
PL215125B1
申请日:
2002.08.20
申请国别(地区):
PL
年份:
2013
代理人:
摘要：
Disclosed are novel methods for combatting diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protien (APP) or beta amyloid (A²). Immunization is preferably effected by administration of analogues of autologous APP or A², said analogues being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous A² which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Also disclosed are nucleic acid vaccination against APP or A² and vaccination using live vaccines as well as methods and means useful for the vaccination. Such methods and means include methods for the preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations
