Koefoed, Peter,Jensen, Martin Roland,Rasmussen, Peter Birk,Degan, Florence Dal,Nielsen, Klaus Gregorius
申请号：
AU2010212381
公开号：
AU2010212381B2
申请日:
2010.08.16
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2010212381B220120119.pdf#####ABSTRACT Disclosed are novel methods for combatting diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protein (APP) or 5 beta amyloid (AP). Immunization is preferably effected by administration of analogues of autologous APP or A$, said analogues being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous As which has been modified by io introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Also disclosed are nucle:'.c acid vaccination against APP or AP and vaccination using live vaccines as well as methods and means useful f or the vaccination. Such methods and means include methods for the 15 preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.
