THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERV
发明人:
Christian S. Hinrichs,Steven A. Rosenberg
申请号：
US14905138
公开号：
US20160144018A1
申请日:
2014.07.14
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed are methods of preparing an isolated population of human papillomavirus (HPV)-specific T cells comprise dividing an HPV-positive tumor sample into multiple fragments； separately culturing the multiple fragments； obtaining T cells from the cultured multiple fragments； testing the T cells for specific autologous HPV-positive tumor recognition； selecting the T cells that exhibit specific autologous HPV-positive tumor recognition； and expanding the number of selected T cells to produce a population of HPV-specific T cells for adoptive cell therapy. Related methods of treating or preventing cancer using the T cells are also disclosed.
