BAKhMANN Shtefan (CH),БАХМАНН Штефан (CH),FLOR Aleksandr (DE),ФЛОР Александр (DE),GREBKE TsBINDEN Katrin (CH),ГРЁБКЕ ЦБИНДЕН Катрин (CH),KERNER Mattias (DE),КЁРНЕР Маттиас (DE),KUN Bernd (CH),КУН Берн,BAKHMANN SHTEFAN,БАХМАНН Штефан,FLOR ALEKSANDR,ФЛОР Александр,GREBKE TSBINDEN KATRIN,ГРЁБКЕ ЦБИНДЕН Катрин,KERNER MATTIAS,КЁРНЕР Маттиас,KUN BERND,КУН Бернд,PETERS JENS-UVE,ПЕТЕРС Йенс-Уве,RUDOLF MARK
申请号：
RU2014110943/04
公开号：
RU0002567396C1
申请日:
2012.09.03
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to formula compound, in which X and X1 independently represent CR4 or N； Y and Y1 independently represent C or N； Z and Z1 independently represent CR6, NR7, N, O or S； R1 and R2 are independently selected from C1-C7-alkyl, C3-C8-cycloalkyl, or R1 and R2, together with nitrogen atom, they are bound to, form spirobicyclic saturated ring system, including from 5 to 12 ring atoms, including heteroatoms, selected from N, O, or 4-, 5- or 6-membered heterocycloalkyl, containing 1 or 2 heteroatoms, selected from N, O, S, which can contain from 1 to 3 substituents, independently selected from halogen； R3 represents C1-C7-alkyl； R4 represents hydrogen, C1-C7-alkyl, C1-C7-halogenalkyl or halogen； R5 represents phenyl or heteroaryl, with both groups probably containing C1-C7-alkyl, halogen, C1-C7-alkoxygroup as substituent； R6 represents hydrogen, C1-C7-alkyl or R5 and R6, together with Y1 and Z atom, which they are bound to, form phenyl ring, possibly substituted with C1-C7-alkyl, halogen； R7 represents C1-C7-alkyl, C3-C8-cycloalkyl, C1-C7-halogenalkyl, C1-C7-alkoxyalkyl, phenyl, heteroaryl or C1-C7-alkyl, possibly substituted with phenyl or C3-C8-cycloalkyl, or R5 and R7, together with Y1 and Z atom, which they are bound to, form heteroaryl, possibly substituted with C1-C7-alkyl, C1-C7-halogenalkyl； W is selected from ethylene, possibly substituted with C1-C7-alkyl, and to its physiologically acceptable salts.EFFECT: claimed compounds inhibit PDE 10A phosphodiesterase and can be applied as medications.18 cl, 65 ex, 1 tblИзобретение относится к соединению формулы (I), в котором X и Х1 независимо представляют собой CR4 или N； Y и Y1 независимо представляют собой C или N； Z и Z1 независимо представляют собой CR6, NR7, N, О или S； R1 и R2 независимо выбраны из C1-C7-алкила, C3-C8-циклоалкила, или R1 и R2, совместно с атомом азота, к которому они присоединены, образуют спиробициклическую насыщенную кольцевую систему, включающую от 5
