BACHMANN, STEPHAN,FLOHR, ALEXANDER,GROEBKE ZBINDEN, KATRIN,KOERNER, MATTHIAS,KUHN, BERND,PETERS, JENS-UWE,RUDOLPH, MARKUS
申请号：
ES12758435
公开号：
ES2550201T3
申请日:
2012.09.03
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of the formula (I) ** Formula ** in which: X and X1 are independently CR4 or N； Y and Y1 are independently C or N； Z and Z1 are independently CR6, NR7, N, O or S； R1 and R2 are independently selected from hydrogen, C1-C7 alkyl, C3-C8 cycloalkyl, C1-C7 haloalkyl, (C1-C7 alkoxy) -C1-C7 alkyl, heterocycloalkyl or C1-C7 alkyl optionally substituted by aryl or heteroaryl or R1 and R2, together with the nitrogen atom to which they are attached, form a bicyclic ring system or a heterocycloalkyl, which may be substituted by 1-3 substituents independently selected from the group consisting of hydroxyl, halogen, C1-C7 alkyl , C1-C7 alkoxy, C1-C7 haloalkyl and oxo； R3 is hydrogen or C1-C7 alkyl； R4 is hydrogen, C1-C7 alkyl, C3-C8 cycloalkyl, C1-C7 haloalkyl or halogen； R5 is aryl or heteroaryl, both groups are optionally substituted by C1-C7 alkyl, C3-C8 cycloalkyl, halogen, C1-C7 haloalkyl, C1-C7 alkoxy, hydroxyl, hydroxy C1-C7 alkyl, C1-C7 alkoxyalkyl, acetyl, cyano, amino optionally substituted by one or two C1-C7 alkyl groups； R6 is hydrogen, halogen, C1-C7 alkyl, C3-C8 cycloalkyl, C1-C7 alkoxy, C1-C7 haloalkyl, C1-C7 alkoxyalkyl, heterocycloalkyl, aryl, heteroaryl or C1-C7 alkyl optionally substituted by aryl, heteroaryl, heterocycloalkyl, cycloalkyl or R5 and R6, together with the groups Y1 and Z to which they are attached, form an aryl or heteroaryl, both groups are optionally substituted by C1-C7 alkyl, halogen, C1-C7 alkoxy, C1-C7 haloalkyl； R7 is hydrogen, halogen, C1-C7 alkyl, C3-C8 cycloalkyl, C1-C7 alkoxy, C1-C7 haloalkyl, C1-C7 alkoxyalkyl, heterocycloalkyl, aryl, heteroaryl or C1-C7 alkyl optionally substituted by aryl, heteroaryl, heterocycloalkyl, cycloalkyl or R5 and R7, together with the groups Y1 and Z to which they are attached, form an aryl or heteroaryl, both groups are optionally substituted by C1-C7 alkyl, halogen, C1-C7 alkoxy, C1-C7 haloalkyl； W is chosen from ethylene and ethenylene, both are optionally substituted by C1-C7 alkyl or halog
