HORWELL DAVID CHRISTOPHER,호르웰, 데이비드 크리스토퍼,SCOPES DAVID IAN CARTER,스콥스, 데이비드 이안 카터
申请号：
KR1020127030542
公开号：
KR1020130094206A
申请日:
2011.05.16
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
A compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof wherein X is N or CH； Q is NR6 or O； A1 and A2 are independently hydrogen or C1-6 alkyl or may together form a carbonyl group； R1 and R2 are independently hydrogen, halogen, CF3, CN, OR7, OR8, NR8R9, NR8COR10, NR8S02R10, S02NR8R9, SO2R10 or C1-6 alkyl optionally and independently substituted by one or more of hydroxyl, C1-6 alkoxy, halogen or NR8 R9； R 3 is hydrogen, halogen, CF3 or OR 7； R4 is hydrogen, halogen, CF3, OR8, NR8R9, NR8COR10, NR8S02R10 or C1-6 alkyl optionally substituted by hydroxyl, C1-6 alkoxy or NR 8 R 9； or when R3 and R4 are positioned ortho and taken together form -0(CH2)mO-, where m is 1-3； R5 is hydrogen or C1-6 alkyl optionally substituted by hydroxyl, C1-6 alkoxy or NR8 R9； R6 is hydrogen or C1-6 alkyl； R7 is hydrogen or C1-6 alkyl optionally substituted by OR8 or NR8R9； R8 is hydrogen, C1-6 alkyl, optionally substituted by hydroxyl or C1-6 alkoxy or C1-3 alkylphenyl wherein said phenyl group is optionally substituted by one or more substituents selected from halogen, C1-6 alkyl, CF3, OR7, NR8R9 or OCF3； or the groups R8 and R9 when they are attached to a nitrogen atom may together form a 5- or 6-membered ring which optionally contains one further heteroatom selected from NR7, S and O said 5 or 6 membered ring being optionally substituted by hydroxyl or C1-6 alkoxy； or the groups R8 and R9 when they are attached to a nitrogen atom may together form an azetidinyl ring optionally substituted by hydroxyl or C1-6 alkoxy； and R10 is C1-6 alkyl or a phenyl group optionally substituted by one or more substituents selected from halogen, C1-6 alkyl, CF3, OCF3 or OR7； and n is 1 or 2. The use of the compounds in treating amyloid disease is also disclosed.화학식 (I)의 화합물 또는 이의 약학적으로 허용가능한 염 또는 전구약물: 여기서, X는 N 또는 CH이며； Q는 NR6 또는 O이며； A1 및 A2는 독립적으로 수소 또는 C1-6 알킬이거나 또는 함께 카보닐 그룹을 형성할 수 있으며； R1및 R2는 독립적으로 수소, 할로겐, CF3, CN, OR7, OR8, NR8R9, NR8COR10, NR8SO2R10, SO2NR8R9, SO2R10
