SILVA GUISASOLA LUIS OCTAVIO,MATEOS BURON LYDIA,LORENTE BONDE LARSEN ANTONIO,GUTIERREZ FUENTES LUIS GERARDO
申请号：
IN439/DELNP/2011
公开号：
IN2011DN00439A
申请日:
2011.01.19
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
Olopatadine can be obtained by means of a process comprising hydrolysis of a compound of general formula (II), wherein Y is OR1, wherein R1 is C1-C7 alkyl, C3-C7 cycloalkyl, aryl, arylalkyl, or heterocycle or NR2R3, wherein R2 and R3, independently from each other, are C1-C7 alkyl, aryl, arylalkyl, or R2 and R3 together with the nitrogen atom to which they are bound form a heterocycle of 3 to 7 members, obtained by means of a process comprising reacting the corresponding ester or amide of 6,11-dihydro-l 1-oxodibenz[b,e]oxepin-2-acetic acid with a suitable Wittig reagent, in the presence of a base in a reaction medium comprising an organic solvent.
