An insulin derivative of general formula I: (Y1-Z1-X1) m-Ins- (XYZ) n wherein n is zero or 1 m is zero or 1 with the proviso that n and m are not both zero Ins represents insulin or an insulin analogue as defined herein which has been removed a hydrogen atom of an ε-amino group present on a lysine residue at B29 and / or present in a lysine residue at A22 and wherein the amino group present at the amino acid residue N-terminal in chain a and / or B optionally substituted by one or two alkyl groups (preferably methyl or ethyl), in which the / those group ( s) of general formula -XYZ and / or -X1-Y1-Z1 is (are) bonded (s) to a group ε-amino Lys residue (K) in the insulin molecule X and X1 independently of one another, is a bond, a radical of general formula -CO- (C1-C3) -CH (COOH) -NH- in which the amino group is attached to the radical Y / Y1 or a radical of the general formula -CO- (C1-C3) -SO2-NH-, wherein the amino group is connected to the radical Y / Y1 Y and Y1, independently of one another, is an ω-aminoalkanoyl group containing from 6 to 22 carbon atoms and in which a hydrogen atom has been removed ω-amino group and Z and Z1, independently, is a group of one of the two following general formulas, -SO2-Ar or -CO-Ar in which Ar is a phenyl group substituted with one or more groups -B (OH) 2 and optionally substituted with one or more halogen atoms.Un derivado de insulina de fórmula general I: (Z1-Y1-X1)m-Ins-(X-Y-Z)n en la que n es cero o 1 m es cero o 1 con la condición de que n y m no sean ambos cero Ins representa insulina o un análogo de insulina tal como se define en el presente documento del que se ha eliminado un átomo de hidrógeno de un grupo ε-amino presente en un residuo de lisina en B29 y/o presente en un residuo de lisina en A22 y en la que el grupo amino presente en el residuo de aminoácido N-terminal en la cadena A y/o B, opcionalmente, está sustituido con uno o dos grupos alquilo (preferiblemente metilo o etilo), en la que el/los grupo(s) de fórm
