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New bicyclic dihydroquinolin-2-one derivatives
专利权人:
F. Hoffmann-La Roche AG
发明人:
AEBI, Johannes,AMREIN, Kurt,FANTASIA, Serena,HORNSPERGER, Benoit,KUHN, Bernd,LIU, Yongfu,MAERKI, Hans P.,MAYWEG, Alexander,Mohr, Peter,SCALONE, Michelangelo,TAN, Xuefei,ZHOU, Mingwei
申请号:
ES12766628
公开号:
ES2666802T3
申请日:
2012.09.20
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Compounds of formula (I) ** Formula ** in which R1 is C1-C7 alkyl; R2 is H; R3 is H; R4 is H; R5 is H; R6 is H, halogen or C1-C7 alkyl; R7 is H; R8 is H; R9 is H; R10 is H; R11 is H; R12 is H or halogen; A1 is CR13; A2 is NR14 or CR15R16; A3 is CR17; R13 is H or halogen; R14 is - (CR20R21) q- (CR22R23) r- (CR24R25) p-NR26R27, in which the sum of q, r and p is at least 2; R15 is - (CR20R21) q- (CR22R23) r- (CR24R25) p-NR26R27; R16 is H; or R6 and R16, together with the carbon atoms to which they are attached, form a double bond; R17 is H; R20 is H; R21 is H R22 is H; R23 is H; R24 is H; R25 is H; R26 is H; R27 is H, -S (O) 2R31, -C (O) R31 or -C (O) OR31, where in case R26 is H and R27 is H, then the sum of q, ryp is at least one; R31 is C1-C7 alkyl, C1-C7 hydroxylalkyl, C3-C8 cycloalkyl or chloropyridinyl; n is zero or 1; p is zero or 1; q is zero or 1; r is zero or 1; or pharmaceutically acceptable salts or esters.Compuestos de fórmula (I) **Fórmula** en la que R1 es alquilo C1-C7; R2 es H; R3 es H; R4 es H; R5 es H; R6 es H, halógeno o alquilo C1-C7; R7 es H; R8 es H; R9 es H; R10 es H; R11 es H; R12 es H o halógeno; A1 es CR13; A2 es NR14 o CR15R16; A3 es CR17; R13 es H o halógeno; R14 es -(CR20R21)q-(CR22R23)r-(CR24R25)p-NR26R27, en la que la suma de q, r y p es al menos 2; R15 es -(CR20R21)q-(CR22R23)r-(CR24R25)p-NR26R27; R16 es H; o R6 y R16, junto con los átomos de carbono a los que están unidos, forman un doble enlace; R17 es H; R20 es H; R21 es H R22 es H; R23 es H; R24 es H; R25 es H; R26 es H; R27 es H, -S(O)2R31, -C(O)R31 o -C(O)OR31, en la que en caso de que R26 sea H y R27 sea H, entonces la suma de q, r y p es al menos 1; R31 es alquilo C1-C7, hidroxilalquilo C1-C7, cicloalquilo C3-C8 o cloropiridinilo; n es cero o 1; p es cero o 1; q es cero o 1; r es cero o 1; o sales o ésteres farmacéuticamente aceptables.
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