Kanski, Jaroslaw,Guenther, Sven,Mickle, Travis,Bera, Sanjib,Martin, Andrea
申请号:
NZ73158615
公开号:
NZ731586A
申请日:
2015.12.02
申请国别(地区):
NZ
年份:
2018
代理人:
摘要:
The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxymorphone (4,5-α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one) to form novel prodrugs/compositions of oxymorphone, including benzoates, salicylates, propionates, fenamates, and acetates, which have a decreased potential for abuse of oxymorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.