NOVEL INHIBITORS FOR ERG ONCOGENE POSITIVE CANCERS

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专利权人:

The Henry M. Jackson Foundation for the Advancement of Military Medicine; Inc.

发明人:

Clifton DALGARD,Ahmed MOHAMED,Meera SRIVASTAVA,Shiv SRIVASTAVA

申请号：

US15125438

公开号：

US20170071920A1

申请日:

2015.03.12

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Alterations to the ERG gene are some of the most prominent genomic changes associated with many cancers including prostate cancer. Such cancer specific alterations result in the overexpression of wild type ERG protein or an altered ERG protein. The present invention provides selective inhibitors of wild type or an altered ERG protein expression. The ERG inhibitors of the invention, therefore, are therapeutic agents for treating ERG positive cancers.

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