THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE; INC.
发明人:
DOBI, ALBERT L.,DALGARD, CLIFTON,SRIVASTAVA, SHIV
申请号：
CA2981188
公开号：
CA2981188A1
申请日:
2016.09.09
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Selective azophenol inhibitors of a wild type or an altered ERG protein expression are described, where the inhibitors represent a compound of Formula (I) or Formula (II), wherein X, X1, X2, X3, X4, X5, R1 through R4 and R9 are as described. An aspect of the present invention relates to a method for treating a disease associated with overexpression of wild type ERG protein, an altered ERG protein, ERG gene transcription or ERG mRNA translation in a subject suffering therefrom, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or Formula (II)
