Fusion proteins comprising CD4 minimal modules and human immunodeficiency virus (HIV) Tat scaffold polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutralization epitopes
Susan Barnett,Rino Rappuoli,Victoria A. Sharma,Indresh K. Srivastava,Jan Zur Megede
申请号：
US11883696
公开号：
US08168194B2
申请日:
2006.02.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Hybrid molecules comprising CD4 minimal modules or mimetics that bind to HIV Env polypeptides in combination with one or more HIV Tat polypeptides are described. Also described are complexes of these hybrid molecules with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides.
