Fusion proteins comprising CD4 minimal modules and invasin polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutraliziation epitopes
Vega Masignani,Maria Scarselli,Barbara Capecchi,Victoria Sharma,Susan W. Barnett,Indresh K. Srivastava,Rino Rappuoli
申请号：
US11597340
公开号：
US08206720B2
申请日:
2005.06.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
