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High-concentration protein formulations and method of manufacture
专利权人:
Jeffrey B. Etter;John F. Carpenter;Adrian C. Samaniego
发明人:
John F. Carpenter,Jeffrey B. Etter,Adrian C. Samaniego
申请号:
US10271832
公开号:
US08372798B2
申请日:
2002.10.16
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Provided is a pharmaceutical composition involving a concentrated mixture of a precipitated protein and a liquid medium and a method for manufacturing the concentrated mixture. The concentrated mixture is manufacturable by precipitation of a protein with a biocompatible polymer precipitating agent, followed by removal of sufficient liquid to concentrate the resulting mixture to the desired degree. The precipitated protein can be stored for a significant time in the concentrated mixture, such as intermediate between processing stages during manufacture operations.
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