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Process for lowering the viscosity of highly concentrated protein solutions
专利权人:
发明人:
Emmanuel DAUTY,Thomas BALLET,Remi Soula
申请号:
US13962324
公开号:
US20140044708A1
申请日:
2013.08.08
申请国别(地区):
US
年份:
2014
代理人:
摘要:
A process of lowering the viscosity of a solution includes preparing a solution comprising a compound of formula I, at a concentration in the final formulation of between 10 and 250 mM, and a protein having at least one antibody fragment whose concentration is between 50 and 350 mg/mL and whose pH is between 5 and 8.The compound lowers the viscosity of the solution, which is difficult to inject, by a value of at least 15% relative to the viscosity of a solution of at least one protein having at least one antibody fragment of the same concentration and of the same pH not containing the compound.
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