An energizing food supplement that comprises creatine, taurine, caffeine, ashwagandha (withania somnifera) extract, milk thistle (silybum marianum) extract, willow (salix alba) extract, vitamin B12, vitamin B6, vitamin B1, fructose and optionally one or more excipients, in a physiologically acceptable carrier. The invention further relates to such supplement for use in the prevention and treatment of the effects of a hangover.