The present invention relates to a Lactuca sativa seed designated 41-108 RZ, which exhibits resistance against downy mildew (Bremia lactucae) races B1:1 to B1:28, CA-I, CA-IIA, CA-IIB, CA-III, CA-IV, CA-V, CA-VI, CA-VII, CA-VIII, currant-lettuce aphid (Nasonovia ribisnigri) biotype Nr:0, root aphid (Pemphigus bursarius), and lettuce mosaic virus (LMV) race LMV:1, and intensely red leaves. The present invention also relates to a Lactuca sativa plant produced by growing the 41-108 RZ seed. The invention further relates to methods for producing the lettuce cultivar, represented by lettuce variety 41-108 RZ.