The present invention relates to a Lactuca sativa seed designated 41-112 RZ, which exhibits a combination of traits including resistance to downy mildew races Bl:1 to Bl:28, CA-I, CA-IIA, CA-IIB, CA-III, CA-IV, CA-V, CA-VI, CA-VII, CA-VIII (Bremia lactucae Regel), currant-lettuce aphid (Nasonovia ribisnigri) biotype Nr:0, root aphids (Pemphigus bursarius), corky root rot (Sphingomonas suberifaciens), and Fusarium (Fusarium oxysporum f. sp. lactucae) race Fol:1. The present invention also relates to a Lactuca sativa plant produced by growing the 41-112 RZ seed. The invention further relates to methods for producing the lettuce cultivar, represented by lettuce variety 41-112 RZ.