The present invention relates to a Lactuca sativa seed designated 41-153 RZ, which exhibits resistance to downy mildew races B1:1 to B1:28, CA-I, CA-IIA, CA-IIB, CA-III, CA-IV, CA-V, CA-VI, CA-VII, CA-VIII (Bremia lactucae Regel), currant-lettuce aphid (Nasonovia ribisnigri) biotype Nr:0, and corky root race CA1. The present invention also relates to a Lactuca sativa plant produced by growing the 41-153 RZ seed. The invention further relates to methods for producing the lettuce cultivar, represented by lettuce variety 41-153 RZ.