BOLLBUCK, BIRGIT,DENHOLM, ALASTAIR NOVARTIS,EDER, JÖRG,HERSPERGER, RENÉ,JANSER, PHILIPP,REVESZ, LÁSZLO,SCHLAPBACH, ACHIM,WÄLCHLI, RUDOLF
申请号：
ES04726485
公开号：
ES2527882T3
申请日:
2004.04.08
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula IIIa or IIIb or a pharmaceutically acceptable salt thereof ** Formula ** wherein R2 "is optionally substituted by phenyl, thiophenyl, benzothiophenyl, pyridinyl, naphthalenyl or indolyl, wherein R2" is optionally substituted by one or more R20 substituents independently selected from OH, halogen, CN, NO2, or (optionally substituted C1-C7 alkyl (including cycloalkyl), C2-C7 alkene, C2-C7 alkyne, C1-C7 alkoxy, C2-C7 alkynyloxy, C2-C7 alkynyloxy , aryl carboxylic, heteroaryl or heterocycloalkyl, NH2 (optionally mono- or disubstituted by a C1-C7 alkyl, aryl carboxylic, heteroaryl, aryl-C1-C7 alkyl, heterocycloalkyl or heterocycloalkyl-C1-C7 alkyl), or -C (O) -Rx, -OC (O) -Rx, -S (O) -Rx, -S (O) 2-Rx, -CH2-O-Rx or - NH-C (O) -Rx, where Rx is OH, C1-C7 alkoxy, carbocyclic or heterocyclic aryloxy, carbocyclic or heterocyclic aryl-C1-C7 alkoxy, or NH2 optionally mono or disubstituted by a C1-C7 alkyl, carbocyclic aryl or heter occyclic, C1-C7 carbocyclic or heterocyclic arylalkyl, heterocycloalkyl or heterocycloalkyl-C1-C7 alkyl)； wherein R20 is optionally substituted by one or more R21 substituents independently selected from OH, halogen, CN, NO2, or (optionally substituted C1-C7 alkyl (including cycloalkyl), C2-C7 alkene, C2-C7 alkyne, C1-C7 alkoxy , C2-C7 alkenyloxy, C2-C7 alkynyloxy, aryl carboxylic, heteroaryl, heterocycloalkyl, NH2 (optionally mono- or disubstituted by a C1-C7 alkyl, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic-C1-C7 alkyl, heterocycloalkyl or heterocycloalkyl -C1-C7 alkyl), or - C (O) -Rx, -OC (O) -Rx, -S (O) -Rx, -OS (O) -Rx, -CH2-O-Rx or -NHC ( O) -Rx, where Rx is as defined above), and where R21 is optionally substituted by one or more R22 substituents independently selected from OH, halogen, CN, NO2, or C1-C7 alkyl (including cycloalkyl), C1 alkoxy -C7, aryl carboxylic, heteroaryl, or heterocycloalkyl, NH2 (optionally mono- or disubstituted by a C1-C7 alkyl, carbocyclic or heterocyclic aryl co, C1-C7 carbocy
