LIM, Hyung Kyu,KIM, Hyun Uk,LEE, Mi Kyoung,LEE, Jong Soo,BAE, Sung Min,KWON, Se Chang
申请号：
HUE13822545
公开号：
HUE045837T2
申请日:
2013.07.25
申请国别(地区):
HU
年份:
2020
代理人:
摘要：
The present invention relates to a liquid formulation of a combination of long-acting insulin and insulinotropic peptide, comprising insulin which is a physiologically active peptide, insulinotropic peptide, and albumin-free stabilizer, wherein the stabilizer comprises a buffer, a sugar alcohol, a non-ionic surfactant, and an isotonic agent； and a method for preparing the liquid formulation. The liquid formulation of the present invention does not contain a human serum albumin and potentially toxic factors to the body, and thus it has excellent storage stability for insulin conjugate and insulinotropic peptide conjugate at high concentration, without a risk of viral contamination.
