ISHIZUKA, NATSUKI,石塚夏树,石塚夏樹,SASATANI, TAKASHI,笹谷隆司,笹谷隆司,HIRAMATSU, YOSHIHARU,平松义春,平松義春,INAGAKI, MASANAO,稻垣雅尚,稻垣雅尚,ODAN, MASAHIDE,大段正英,大段正英,HASHIZUME, HIROSHI,桥诘浩,橋詰浩,MITSUMORI, SUSUMU,光森进,光森進,FUJII, Y
申请号：
TW094137619
公开号：
TWI360539B
申请日:
2005.10.27
申请国别(地区):
TW
年份:
2012
代理人:
摘要：
[Lesson Questions]The bright first of amine containing the 3- anilide -2- Pyridione derivatives and The compounds As effective components Medical Drug Group for being provided with great Ma Alkaline Shou the sharp Move effects of Body of this Hair control Treatment Elixirs, Kang Sao Itch Elixirs, special As The mouthfuls of Kang Sao Itch Elixirs and external application Kang Sao Itch Elixirs at object, Iso Xing Pi Skin inflammation. [Xie Decision means]As compound, its System Drug of following formula (I) hold Xu Which or its molten Elixirs conjunctions object:(the C1-C8 alkyl etc. that R1 As can be substituted in formulaR2 As C1-C6 alkylR3 As C1-C6 alkyl etc.Or R2 and R3 can be total to 5 ~ 10 STAFF non-aromatic carbon Ring that formation can be substitutedR4 As Hydrogen etc.G As such as following formula bases:(R5 As Hydrogen etc. in formulaX1 As Single Key etc.X2 As can have Zhong Jie with 1 or 2 Ge-O- or-N (R6)-(R6 As Hydrogen etc.), can substituted C1-C8 stretch alkyl etc.X3 As Single Key etc.) etc.).【課題】本發明提供有大麻鹼受體激動作用之含3-胺甲醯基-2-吡啶酮衍生物及該化合物為有效成分之醫藥組成物、異位性皮膚炎治療劑、抗搔癢劑,特為經口抗搔癢劑及外用抗搔癢劑。【解決手段】如下式(I)之化合物、其製藥容許鹽或其溶劑合物:(式中R1為可有取代之C1-C8烷基等;R2為C1-C6烷基;R3為C1-C6烷基等;或R2及R3可共形成可有取代之5~10員非芳香族碳環;R4為氫等;G為如下式基:(式中R5為氫等;X1為單鍵等;X2為可有仲介以1或2個-O-或-N(R6)-(R6為氫等),可有取代之C1-C8伸烷基等;X3為單鍵等)等)。
