The bright Ti Gong mono- Seed of this Hair have Gifted Iso Very light kinases A Election Select inhibiting effect, as can Enough Kou Fu Give Drug the useful new compound And of anticancer Elixirs and, Ti increases Strong Elixirs Ji And Treatment method Gong the Xin Xing Kang Swollen tumor effect that Yi Seed includes the micro-pipe effect Drug of taxane Class anticancer Elixirs. One Seed leads to piperidine compounds or its Which shown in formula (I). (in formula,R1 expression carboxyl,- C (=O) NR5R6,Or it can have C1-C6 alkyl or trifluoromethyl as substituent group oxadiazolyl； R2 Biao Shi Halogen element atom or C1-C6 alkoxy； R3 indicate can with tool have Election from Halogen element atom,C1-C6 alkyl,Phenyl of 1~3 identical or different Ge as substituent group in C1-C6 alkoxy and trifluoromethyl Ji Mission； R4 indicates Hydrogen atom or C1-C6 alkyl； R5 and R6 are identical or different,Expression Hydrogen atom,C1-C6 alkyl or C3-C6 Ring alkyl,Or the nitrogen-atoms of R5 and R6 Ke Yi With Knot conjunction is formed together 3~6 yuan of nitrogenous Eat He Miscellaneous Ring yl).本發明提供一種具有優異的極光激酶A選擇性抑制作用、作爲能夠口服給藥的抗癌劑有用的新型化合物，並且，提供一種包含紫杉烷類抗癌劑的微管作用藥的新型抗腫瘤效果增強劑及並用療法。一種通式(I)所示的哌啶化合物或其鹽。(式中，R1表示羧基、－C(＝O)NR5R6、或可以具有C1－C6烷基或者三氟甲基作爲取代基的噁二唑基；R2表示鹵素原子或C1－C6烷氧基；R3表示可以具有選自鹵素原子、C1－C6烷基、C1－C6烷氧基和三氟甲基的基團中的相同或不同的1～3個作爲取代基的苯基；R4表示氫原子或C1－C6烷基；R5和R6相同或不同，表示氫原子、C1－C6烷基或C3－C6環烷基，或R5和R6可以與結合的氮原子一起形成3～6元的含氮飽和雜環基)。
