LEARMONTH, David Alexander,KISS, Laszlo Erno,PALMA, Pedro Nuno Leal,FERREIRA, Humberto dos Santos,SILVA, Patrício Manuel Vieira Araújo Soares da
申请号：
ES07834911
公开号：
ES2644049T3
申请日:
2007.10.10
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula I ** (See formula) ** where R1 and R2 are hydrogen； X signifies a methylene group； Y represents an oxygen or sulfur atom； n represents the number 0, 1, 2 or 3 and m represents the number 0 or 1； R3 means a pyridine N-oxide group according to formula A, B, or C, which is connected as indicated by the unlabeled bond: ** (See formula) ** where R4, R5, R6 and R7 are the same or different, and signify hydrogen, a C1-C6 alkyl group, C1-C6 thioalkyl, a C1-C6 alkoxy aryloxy or thioaryl group, a C1-C6 alkanoyl or aroyl group, an optionally substituted aryl group, an amino group, alkyl (C1-C6) amino, dialkyl (C1-C6) amino, cycloalkylamino or heterocycloalkylamino, a (C1-C6) alkylsulfonyl or arylsulfonyl group, halogen, a haloalkyl, trifluoromethyl, cyano, nitro or heteroaryl group, or taken together mean rings aliphatic or heteroaliphatic or aromatic or heteroaromatic rings； the term "alkyl" means straight or branched carbon chains containing from one to six carbon atoms； the term aryl means an optionally substituted phenyl or naphthyl group, alkoxy or halogen groups； the term heterocycloalkyl represents a four to eight membered cyclic ring optionally incorporating other oxygen, sulfur or nitrogen atoms； the term heteroaryl represents a five or six membered ring incorporating a sulfur, oxygen or nitrogen atom； the term halogen represents fluorine, chlorine, bromine, or iodine； or a pharmacologically acceptable salt thereof, for use in the prevention or treatment of disorders associated with the central and peripheral nervous system, wherein said compound is administered to a human according to a dosing regimen having a dosing periodicity in the range from twice daily up to once every other day with an effective daily dose of 1 to 1000 mg / day.Un compuesto de fórmula I **(Ver fórmula)** donde R1 y R2 son hidrógeno； X significa un grupo metileno； Y representa un átomo de oxígeno o azufre； n representa el número 0, 1, 2 o 3 y m representa el número 0 o 1；
