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2-9 DIAMINO PYRIMIDIN 5 YL CARBOXAMIDES AS SYK OR JAK KINASES INHIBITORS
专利权人:
PORTOLA PHARMACEUTICALS; INC.
发明人:
BAUER, SHAWN, M.,JIA, ZHAOZHONG, J.,SONG, YONGHONG,XU, QING,MEHROTRA, MUKUND,ROSE, JACK, W.,HUANG, WOLIN,VENKATARAMANI, CHANDRASEKAR,. PANDEY, ANJALI
申请号:
TN2010000469
公开号:
TN2010000469A1
申请日:
2010.10.14
申请国别(地区):
TN
年份:
2012
代理人:
摘要:
The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as cardiovascular disease, inflammatory disease, autoimmune disease and cell proliferative disorder, thrombosis, allergy, asthma, rheumatoid arthritis, leukemia, or non-Hodgkins lymphoma.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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