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6,2–דיאמינו–פירימידינ–5–יל–קרבוקסאמידים כמעכבי syk או jak קינאזות
专利权人:
PORTOLA PHARMACEUTICALS INC.
发明人:
申请号:
IL25165517
公开号:
IL251655A
申请日:
2017.04.09
申请国别(地区):
IL
年份:
2020
代理人:
摘要:
The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as cardiovascular disease, inflammatory disease, autoimmune disease and cell proliferative disorder, thrombosis, allergy, asthma, rheumatoid arthritis, leukemia, or non-Hodgkin's lymphoma.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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