Novel 2,3-dihydro-1H-imidazo {1,2-a} pyrimidin-5-one and this 1,2,2,4-tetrahydropyrimido {1,2-a} pyrimidin-6-one derivatives comprising a morpholine substituted, preparation thereof and pharmaceutical use thereof
EL-AHMAD, Youssef,FILOCHE-ROMME, Bruno,LETALLEC, Jean-Philippe,MARCINIAK, Gilbert,RONAN, Baptiste,VIVET, Bertrand,BROLLO, Maurice
申请号：
ES13773341
公开号：
ES2662803T3
申请日:
2013.06.21
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
Products of formula (I): ** (See formula) ** in that: p and q are the whole numbers 0 or 1 or 2 so that, if p>； = 0, then q>； = 1 or 2 and, if p>； = 1 or 2, then q>； = 0； R1 is chosen from the following values a) to e): a) R1 is a phenyl or pyridyl radical optionally substituted with one or more radicals, which may be identical or different, chosen from halogen atoms and cycloalkyl, alkyl and alkoxy radicals, being the last alkyl and alkoxy radicals themselves optionally substituted with one or more fluorine atoms； b) R1 is a radical - (CH2) m-Ra where m is the integer 1 or 2 and Ra is an optionally substituted aryl or heteroaryl radical, or a -CO-cycloalkyl, -CO-heterocycloalkyl radical, -CO-Rb, - C (Rb)>； = N-ORc, - CO2Rd or -CONRxRy； c) R1 is an alkenyl radical； cycloalkyl radical； heterocycloalkyl radical； or an alkyl radical optionally substituted with one or more radicals, which may be identical or different, chosen from fluorine atoms and hydroxyl, cycloalkyl, heterocycloalkyl, phenyl, pyridine and alkoxy radicals, the latter being phenyl, pyridine and alkoxy radicals themselves optionally substituted with one or more fluorine atoms； d) R1 is a radical -SO2-Rb； e) R1 is a radical -CO-Re； Rb is an optionally substituted alkyl, cycloalkyl, aryl or heteroaryl radical； Rc is a hydrogen atom or an alkyl radical； Rd is an alkyl or cycloalkyl radical； Re is an optionally substituted alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl radical； NRxRy being such that Rx and Ry, which may be identical or different, are chosen from a hydrogen atom and alkyl, cycloalkyl, alkoxy and phenyl radicals； or Rx and Ry form, with the nitrogen atom to which they are attached, a cyclic radical containing 3 to 7 ring members and optionally one or more other heteroatoms chosen from O, NH and N-alkyl； R2 and R3, which may be identical or different, are chosen from a hydrogen atom and an alkyl radical optionally substituted with one or more fluorine atoms, it being unders
