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Derivatives of 6,7,8,9-tetrahydro-pyrimido {1,2-a} pyrimidin-4-one, its preparation and its pharmaceutical application
专利权人:
SANOFI
发明人:
BACQUE, ERIC,BROLLO, MAURICE,CLAUSS, ANNIE,EL AHMAD, YOUSSEF,FILOCHE-ROMME, BRUNO,HALLEY, FRANK,KARLSSON, KARL ANDREAS,MARCINIAK, GILBERT,RONAN, BAPTISTE,SCHIO, LAURENT,VIVET, BERTRAND,VIVIANI, FABRIC
申请号:
ES10742013
公开号:
ES2487623T3
申请日:
2010.07.01
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
Products of formula (I): in which: R1 represents a radical -L-aryl or -L-heteroaryl, such that L represents: either a simple bond, or a linear or branched alkyl radical comprising from 1 to 6 atoms of carbon and optionally substituted with a hydroxyl radical, or a CO or -CO-Alk- group; either an L'-X group where L 'represents a linear or branched alkyl radical containing from 1 to 6 carbon atoms and X an oxygen or sulfur atom; the aryl and heteroaryl radicals being optionally substituted with one or several identical or different radicals chosen from the halogen atoms and the hydroxyl, CN, nitro, -COOH, -COOalk, -NRxRy, -CONRxRy, -NRxCORy, -NRxCO2Rz, - CORy, alkoxy, phenoxy, alkylthio, alkyl, cycloalkyl and heterocycloalkyl; the latter being alkoxy, phenoxy, alkylthio, alkyl and heterocycloalkyl radicals themselves optionally substituted with one or several identical or different radicals chosen from halogen atoms and NRvRw; the heterocycloalkyl and heteroaryl radicals may also contain an oxo radical; R2 represents a hydrogen atom or an alkyl radical; R3 represents an alkyl radical optionally substituted with one or more halogen atoms; R4 represents a hydrogen atom or a halogen atom; NRxRy being such that Rx represents a hydrogen atom or an alkyl radical and Ry represents a hydrogen atom, a cycloalkyl radical or an alkyl radical optionally substituted with one or more identical or different radicals chosen from the hydroxyl, alkoxy, NRvRw and heterocycloalkyl radicals ; or Rx and Ry form with the nitrogen atom to which they are attached a cyclic radical comprising from 3 to 10 links and optionally one or several different heteroatoms chosen from O, S, NH and N-alkyl, this radical being Cyclic optionally substituted.Productos de fórmula (I): en la que: R1 representa un radical -L-arilo o -L-heteroarilo, tal que L representa : o bien simple enlace, bien un radical alquilo lineal o ramificado que comprende de 1 a 6 átomos de carbono y opcionalmente sustituido con un ra
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