FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to 1-hydroxyimino-3-phenyl-propane derivatives of formulaI, wherein Rrepresents -(CH)-phenyl, m is equal to 0, and phenyl is substituted by 1-3 groups independently specified in C-alkyl or hydroxy, or -(CH)-heteroaryl, wherein n is equal to 0 or 1, and heteroaryl is specified in pyridine, 1H-pyridin-2-one, 1-oxy-pyridine, 1H-pyrimidin-2-one, quinoline and pyrazine, and is ubsubstituted or substituted by 1-3 groups specified in the patent claim； Rrepresents hydrogen or C-alkyl, or when Rrepresents hydrogen, Rrepresents phenyl optionally substituted by C-alkyl； Rrepresents hydrogen； Rrepresents hydrogen or hydroxy； or Rand Rare substituted by a double bond； Ris specified in a group consisting of C-alkyl, C-cycloalkyl, C-alkenyl, halogen-C-alky, optionally substituted phenyl, optionally substituted phenyl-C-alkyl, 5-9-merous heteroaryl containing 1-2 heteroatoms specified in N and S optionally substituted by C-alkyl or oxo, and piperidinyl optionally substituted by C-alkyl, or Rand Rtogether with a carbon atom to which they are attached, form a C-cycloalkyl ring； Rrepresents hydrogen halogen； or Rand Rtogether with a carbon atom to which they are attached, form a cyclic group G, wherein m represents 0 or 2； R- Rare those as specified in the patent claim； Ris specified in hydrogen, halogen and C-alkyl； or their pharmaceutically acceptable salts. The invention also refers to specific compounds specified in cl. 19 of the patent claim, a method for producing the compounds I, a pharmaceutical composition, a method of treating diabetes and using the compounds for producing a medicinal agent.EFFECT: 1-hydroxyimino-3-phenyl-propane derivatives possessing GPBAR1 agonist activity and effective in treating diabetes.26 cl, 516 exИзобретение относится к производным 1-гидроксиимино-3-фенил-пропана формулы I, где Rпредставляет собой -(CH)-фенил, m равно 0 и фенил замещен 1-3 группами, независимо выбранными из C-алкила или гид
