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ETHYNYL DERIVATIVES
专利权人:
에프. 호프만-라 로슈 아게
发明人:
비에만스 바르바라,구바 볼프강,얘슈케 게오르크,리치 안토니오,뤼허 다니엘,비아이라 에릭
申请号:
KR1020167007447
公开号:
KR1017576030000B1
申请日:
2014.09.22
申请国别(地区):
KR
年份:
2017
代理人:
摘要:
The present invention relates to compounds of the general formula (I), or pharmaceutically acceptable salts or acid addition salts thereof, racemic mixtures, or the corresponding enantiomers and / or optical isomers and / or stereoisomers thereof, (I) In this formula, Y is N or CR &apos;; Two, or three, selected from the group consisting of phenyl, pyridinyl having different N-positions, imidazolyl, pyrazinyl, pyrimidinyl, thiophenyl, thiazolyl, pyrazolyl and thiadiazolyl. A 5 or 6 membered aromatic or heteroaromatic ring containing a heteroatom, optionally substituted with 1, 2 or 3 substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy, lower alkoxy substituted by halogen, and NRR ''Substituted; R and R ''independently from each other may be hydrogen or lower alkyl, or they may form a 5 or 6 membered saturated heterocyclic group which may contain additional oxygen, NH or N-lower alkyl groups with the N atom to which they are attached; R 1 is hydrogen, halogen, or lower alkyl substituted by halogen; R 1 '' is hydrogen, halogen, or lower alkyl substituted by halogen; R <; 2 >; is hydrogen, lower alkyl, lower alkoxyalkyl, cycloalkyl or heterocycloalkyl, or a group <; / RTI >; A is -CH 2 -, -CH 2 CH 2 or -C (CH 3)2 - and; R 3 is phenyl or pyridinyl, the N atom of the pyridinyl group may be present at different positions. It has surprisingly been found that the compounds of formula I are useful for the treatment of Parkinson''s disease, anxiety, vomiting, obsessive compulsive disorder, autism, neuroprotection, cancer, depression or type 2 diabetes mellitus receptor 4 (mGluR4) ).본 발명은 하기 화학식 I의 화합물, 또는 이의 약학적으로 허용되는 염 또는 산 부가 염, 라세미체 혼합물, 또는 이의 상응하는 거울상이성질체 및/또는 광학이성질체 및/또는 입체이성질체에 관한 것이다: [화학식 I]상기 식에서,Y는 N 또는 C-R1'이고;G는 페닐, 상이한 N-위치를 갖는 피리딘일, 이미다졸일, 피라진일, 피리미딘일, 티오페닐
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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