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Isoindolinona derivatives
专利权人:
VIIV HEALTHCARE UK LIMITED
发明人:
申请号:
ARP150102292
公开号:
AR101255A1
申请日:
2015.07.20
申请国别(地区):
AR
年份:
2016
代理人:
摘要:
Disclosed compounds and Methods for treating Viral Infections with compositions comprising these compounds useful for HIV.Claim 1: a compound of the formula (1), where: r u00b9 is c u2081 u208b u2086 R u00b2 is alkyl; aryl c u2085 u208b u2081 u2084 c u2083 u208b u2087, cycloalkyl, cicloalquenilo c u2083 u208b u2087, c u2082 u208b u2089 Heterocyclic and heteroaryl c u2082 u208b u2089, each of which is optionally substituted by one to four replaced Efore selected from Halogen, alkyl c u2081 u208b u2086, heteroalquilo c u2081 u208b u2086, or alquileno c u2081 u208b u2086, or heteroalquileno c u2081 u208b u2086,Where the alquileno c u2081 u208b u2086 or heteroalquileno c u2081 u208b u2086 binds to the carbon Atoms adjacent to the c u2085 u208b u2081 u2084 c u2083 u208b u2087 cicloalquenilo cycloalkyl, aryl, heteroaryl or c u2082 u208b u2089 c u2083 u208b u2087, heterocycle, c u2082 u208b u2089 to form a ring, and where each heterocycle, heteroar ILO, heteroalquilo, and heteroalquileno comprises one to three heteroatoms selected from S,U OR N; l is a link or alquileno c u2081 u208b u2083 r u00b3 c u2081 u208b u2086 is H, alkyl, cycloalkyl, aryl c u2085 u208b u2081 u2084, c u2083 u208b u2087, cicloalquenilo c u2083 u208b u2087, c u2082 u208b u2089 Heterocyclic and heteroaryl c u2082 u208b u2089, each of which is optionally substituted by one to four substituents selected From c u2081 u208b u2086 Halogen, alkyl, and where each Heterocyclic and heteroaryl comprises one to three heteroatoms selected from S,N or o.Se dan a conocer compuestos y métodos para el tratamiento de infecciones virales con composiciones que comprenden estos compuestos útiles para VIH. Reivindicación 1: Un compuesto de la fórmula (1), en donde: R¹ es alquilo C₁₋₆; R² es arilo C₅₋₁₄, cicloalquilo C₃₋₇, cicloalquenilo C₃₋₇, heterociclo C₂₋₉, y heteroarilo C₂₋₉, cada uno de los cuales está opcionalmente sustituido por uno a cuatro sustituyentes seleccionados a partir de halógeno, alquilo C₁₋₆, heteroalqui
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