PATRICK ROBERT VERHOEST,ANTONIA FRIEDERIKE STEPAN,GREGORY WAYNE KAUFFMAN,DOUGLAS SCOTT JOHNSON,CHRISTOPHER WILLIAM AM ENDE,MARTIN YOUNGJIN PETTERSSON
申请号：
ARP160100286
公开号：
AR103582A1
申请日:
2016.02.01
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
Compounds, Pharmaceutical compositions, Methods of treatment, Methods Of Synthesis, and intermediaries.Claim 1: a compound characterized by the structure of the formula (1), or pharmaceutically acceptable salts thereof, wherein: X is a heteroaryl (5 to 14 members of 1 - 3) containing heteroatoms r\u00b9, when it allows Chemically, it selects the Group C Consists of hydrogen, halogen, Hydroxy, oxo -, cyano, Nitro, c\u2081\u208b\u2086 sf\u2085 alkyl, optionally substituted,Alquenilo c\u2082\u208b\u2086 optionally replaced, alquinilo c\u2082\u208b\u2086 optionally replaced, Alquiltio c\u2081\u208b\u2086 alkoxy optionally substituted cycloalkyl, optionally substituted c\u2081\u208b\u2086, c\u2083\u208b\u2088 optionally substituted N - (r\u2074) (r\u2075), - N (r\u2074) (C (= o) r\u2075) - C (= o) n (r\u2074) (r\u2075), or - C (= (o) n (r\u2074) r\u2075) - C (= o) - r\u2074, and - C (= o) - or\u2074 r\u00b2\u1d43 and r\u00b2\u1d47 Chemically, when permitted, in each appearance,Are selected independently from the group consisting of hydrogen, halogen, hydroxy -, cyano, Nitro, c\u2081\u208b\u2086 sf\u2085, optionally substituted alkyl, optionally substituted alquenilo c\u2082\u208b\u2086, alquinilo c\u2082\u208b\u2086 optionally replaced, Alquiltio c\u2081\u208b\u2086 optionally replaced, C\u2081\u208b\u2086 alkoxy optionally substituted alkoxy optionally substituted c\u2081\u208b\u2086alquilo c\u2081\u208b\u2086,C\u2083\u208b\u2088 phenyl optionally substituted cycloalkyl, optionally substituted N - (r\u2074) (r\u2075), - N (r\u2074) (C (= o) r\u2075) - C (= o) n (r\u2074) (r\u2075) - or - C (= o) n (r\u2074) (r\u2075) - C r\u2074 (= o) -, - C (= o) - or\u2074 or r\u00b2\u1d43 and r\u00b2\u1d47 along with the carbon Atoms to which together form a cycloalkyl c\u2083\u208b\u2088 Or a heterocicloalquilo (4 to 10 members)Where c\u2083\u208b\u2088 cycloalkyl and heterocicloalquilo (4 to 10) is optionally substituted with one to three r\u2078 r\u2074\u1d43 and r\u2074\u1d47 Che
