Osvaldo Luis Podhajcer,Eduardo Gustavo Alfredo Cafferata,Maria Veronica Lopez,Diego Luis Viale
申请号：
US12298743
公开号：
US08436160B2
申请日:
2007.04.26
申请国别(地区):
US
年份:
2013
代理人:
摘要：
An isolated DNA sequence corresponding to a region of the SPARC gene human promoter from base pair −513 to base pair +35 capable of driving the expression of a heterologous gene of interest, that can be associated to any other promoter sequence, such as radiation responsive sequence, hypoxia responsive sequence and free-radical responsive sequence. The invention also provides constructs and DNA recombinant expression viral vectors, comprising the isolated sequence of the SPARC gene human promoter and at least one heterologous gene operably linked thereto, wherein the promoter sequence drives the expression of the at least one heterologous gene in tumor cells. Pharmaceutical compositions and a method for treating tumors are also provided.
