Consejo Nacional De Investigaciones Cientificas Y Tecnicas (CONICET);Fundacion Instituto Leloir
发明人:
Viale, Diego Luis,Cafferata, Eduardo Gustavo Alfredo,Podhajcer, Osvaldo Luis,Lopez, Maria Veronica
申请号：
AU2007243252
公开号：
AU2007243252B2
申请日:
2007.04.26
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
An isolated DNA sequence corresponding to a region of the SPARC gene human promoter from base pair -513 to base pair +3 5 capable of driving the expression of a heterologous gene of interest, that can be associated to any other promoter sequence, such as radiation responsive sequence, hypoxia responsive sequence and free-radical responsive sequence. The invention also provides constructs and DNA recombinant expression viral vectors, comprising said isolated sequence of the SPARC gene human promoter and at least one heterologous gene operably linked thereto, wherein said promoter sequence drives the expression of the at least one heterologous gene in tumor cells. Pharmaceutical compositions and a method for treating tumors are also provided.
