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SPARC-derived tumor rejection antigenic peptides and medicaments comprising the same
专利权人:
ONCOTHERAPY SCIENCE; INC.
发明人:
Nakatsuru, Shuichi,Ikuta, Yoshiaki,Nishimura, Yasuharu
申请号:
AU2007259667
公开号:
AU2007259667B2
申请日:
2007.06.15
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The object is to identify a peptide derived from SPARC protein which can induce a human cytotoxic (killer) T cell and a helper T cell both reactive to a tumor, and to provide a means for enabling a tumor immunotherapy in a cancer patient having a high level of SPARC expression. Disclosed is a peptide (A) or (B): (A) a peptide which comprises an amino acid sequence depicted in any one of SEQ ID NOs:1-3; and (B) a peptide which comprises an amino acid sequence having the substitution or addition of one or several amino acid residues in a peptide comprising an amino acid sequence depicted in any one of SEQ ID NOs:1-3 and which can induce a killer T cell.
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