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Amide derivatives of compounds of 1-oxa-4,9-diazaspiro undecano having multimodal activity against pain
专利权人:
Laboratorios del Dr. Esteve; S.A.
发明人:
VIRGILI-BERNADO, Marina,ALONSO-XALMA, Monica,ALEGRET-MOLINA, Carlos,ALMANSA-ROSALES, Carmen,MERCE-VIDAL, Ramon
申请号:
ES15725235
公开号:
ES2678770T3
申请日:
2015.06.02
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of general formula (I), ** (See formula) ** where Y is ** (See formula) ** n is 1 or 2; q is 1, 2, 3, 4, 5 or 6; X is a bond, -C (O) O-, -C (O) NR8-, -C (O) -, -O- or -C (R4R4 ') -; R1 is C (O) R5 or S (O) 2R5; R2 is substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclyl; where cycloalkyl, aryl or heterocyclyl if substituted, are substituted by substituents selected from halogen, -R9, -OR9, -NO2, -NR9R9 '' ', NR9C (O) R9', -NR9S (O) 2R9 ', -S (O) 2NR9R9 ', -NR9C (O) NR9'R9' ', -SR9, -S (O) R9, S (O) 2R9, -CN, haloalkyl, haloalkoxy, -C (O) OR9, -C ( O) NR9R9 ',>; = O, - OCH2CH2OH, -NR9S (O) 2NR9'R9' '; R3 and R3 'are independently selected from hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, alkylcycloalkyl substituted or unsubstituted, substituted or unsubstituted alkylheterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted alkylaryl, where cycloalkyl, heterocyclyl or aryl if also substituted in alkylaryl, alkylcycloalkyl or alkylheterocyclyl, are substituted by substituents selected from halogen, -R9 , and -OR9; R4 is hydrogen, -OR8, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, -C (O) OR9, -C (O) NR9R9 ', - NR9C (O) R9 ', -NR9R9' '', unsubstituted heterocyclyl, unsubstituted aryl and unsubstituted cycloalkyl; R4 'is hydrogen, or substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl or substituted or unsubstituted C2-6 alkynyl; ...Un compuesto de fórmula general (I), **(Ver fórmula)** donde Y es **(Ver fórmula)** n es 1 o 2; q es 1, 2, 3, 4, 5 o 6; X es un enlace,
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