您的位置: 首页 > 农业专利 > 详情页

Bicyclic pyrimidone compounds
专利权人:
ГЛЭКСО ГРУП ЛИМИТЕД (GB)
发明人:
ВАНЬ Цзехун (CN),ЛУН Кай (CN),ЧЖАН Сяомин (CN),ЮЙ Хайхуа (CN)
申请号:
RU2014107486/04
公开号:
RU2014107486A
申请日:
2012.07.25
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. The compound of formula (I) Formula (I) or a pharmaceutically acceptable salt thereof, wherein R is H or C-Ci-alkyl, R ′ is H, halogen or C-Ci-alkyl, X is —O— —NH—, N (C-C1-6 alkyl) -, -S- or -CH-, n is 0, 1, 2 or 3 when X is -CH-, n is 1 or 2, Ar is phenyl or heteroaryl, each which is unsubstituted or substituted by one or more groups selected from the group consisting of CN, halogen, OH, -NH, -NHR, -NRR, C-C 1-6 alkyl, C 1 -C 2 alkoxy and C 1 -C 1 haloalkyl, and Y is absent or represents -O -Ar ′, -NH-Ar ′, -N (C-C1-6 alkyl) -Ar ′ or - (CH) -Ar ′, where Ar ′ is phenyl or heteroaryl, each of which is unsubstituted or substituted by one or more groups selected from the group consisting of CN, halogen, OH, -NH, -NHR, -NRR, C-C1-6 alkyl, C-C1-6 alkoxy and Ci-haloalkyl, and in each case, R and R are independently C-C1-6. 2. The compound of claim 1, wherein R is CH.3. The compound of claim 1, wherein R ′ is H.4. The compound of claim 1, wherein X is —O — .5. The compound of claim 1, wherein n is 1 or 2.6. The compound of claim 1, wherein Ar is unsubstituted phenyl or phenyl substituted with one or more groups selected from the group consisting of CN, F, CF, Cl, OMe and CH, or Ar is pyridinyl or thiophenyl, each of which is unsubstituted or is substituted by one or more F.7. The compound of claim 1, wherein Y is absent or Y is —Ο-Αr ′, where Ar ′ is unsubstituted phenyl or phenyl substituted with one or more groups selected from the group consisting of CF, F, Cl, CN and CH , or Ar ′ is pyridinyl or pyrimidinyl, each of which is independently1. Соединение формулы (I)Формула (I)или его фармацевтически приемлемая соль,где R представляет собой Н или C-Cалкил,R′ представляет собой Н, галоген или C-Cалкил,X представляет собой -O- -NH-, -N(C-Cалкил)-, -S- или -CH-,n равно 0, 1, 2 или 3, когда X представляет собой -CH-, n имеет значение 1 или 2,Ar представляет собой фенил или гетероарил, каждый из которых является незамещенным или замещен одной или несколькими группами, выбра
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充