ALAN STUART JESSIMAN,KRISTOFFER MAANSSON,MORTEN DAHL SØRENSEN,PATRICK STEPHEN JOHNSON
申请号：
BR112019000486
公开号：
BR112019000486A2
申请日:
2017.07.11
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
the present invention relates to a compound according to general formula (i), wherein x represents n or ch； r1 is -cn,(c1 -C6) alkyl, (c3 -C7) cycloalkyl, heterocycloalkyl (3 to 7 membered), heteroaryl (5-6 members), (C3 -C7) cyclo (C1 -C4) alkyl alkyl, (3 to 7 membered) heterocycloalkyl - (C 1 -C 4) alkyl or (5-6 membered) heteroaryl - (C 1 -C 4) alkyl； r2 is halogen,cyan, (c1 -C4) alkyl or (c3 -C7) cycloalkyl； r3 is halogen,cyan, (c1 -C4) alkyl, (c 1 -C 4) haloalkyl or (C 3 -C 7) cycloalkyl； R4 is (C1 -C4) alkyl or (C1 -C4) haloalkyl； R5 is (C1 -C6) alkyl,(c3 -C7) cycloalkyl, (c1 -C6) alkyl- (C3 -C7) cycloalkyl, (C3 -C7) cycloalkyl (C1 -C6) alkyl, heterocycloalkyl (3 to 7 membered), phenyl, heteroaryl (5-6 membered) or -ora. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds and to intermediates for the preparation of said compounds.a presente invenção se refere a um composto de acordo com a fórmula geral (i), em que x representa n ou ch； r1 é -cn, (c1?c6)alquil, (c3?c7)cicloalquil, heterocicloalquil (com 3 a 7 membros), heteroaril (com 5 a 6 membros), (c3?c7)cicloalquil(c1?c4)alquil, heterocicloalquil (com 3 a 7 membros)-(c1?c4)alquil ou heteroaril (com 5 a 6 membros)-(c1?c4)alquil； r2 é halogênio, ciano, (c1?c4)alquil ou (c3?c7)cicloalquil； r3 é halogênio, ciano, (c1?c4)alquil, (c1?c4)haloalquil ou (c3?c7)cicloalquil； r4 é (c1?c4)alquil ou (c1?c4)haloalquil； r5 é (c1?c6)alquil, (c3?c7)cicloalquil, (c1?c6)alquil-(c3?c7)cicloalquil, (c3?c7)cicloalquil-(c1?c6)alquil, heterocicloalquil (com 3 a 7 membros), fenil, heteroaril (com 5 a 6 membros) ou -ora. a invenção se refere ainda aos referidos compostos para uso em terapia, a composições farmacêuticas compreendendo os referidos compostos e a intermediários para a preparação dos referidos compostos.
